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Therapeutic Microcapsules and Nanoparticles

  Our group investigates multi-modality contrast agents based on nanoparticles for targeted imaging and treatment; generation of uniform micro-and nano-spheres and microcapsules of precisely controlled size, shell thickness, charge, and porosity for biomedical  applications

Research Interests

Monodisperse Microcapsules for Biomedical Applications

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Microcapsules of precisely controlled size, shell thickness, charge, and porosity were generated using various natural and synthetic biomaterials suitable for each biomedical application.

Highlighted Projects

  • Microcapsule-mediated porcine islet transplantation for improved type-1 diabetes treatment (Pubmed).

  • Investigation of co-encapsulation for improved survival of anchorage-dependent cells (Pubmed). 

  • Controlled release of biocontrol agents for the development of effective plant disease management (Pubmed).

  • Investigation of enzymatic degradation of hydrogel matrix for controlled drug release (Pubmed). 

Nanoparticles for Diagnosis and Therapy

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Biocompatible nanoparticles were employed to deliver drugs or contrast agents to specific locations of the body unreachable by micro- or macro-scale capsules such as intracellular environment, narrow intravenous pathways, tumor sites, and across the blood-brain barrier. 

Highlighted Projects

  • Nanoparticle-mediated NIR-dye delivery for improved intraoperative cancer imaging and image-guided surgery.

  • Sustained delivery of therapeutic agent-loaded gelatin nanoparticles via intranasal administration for the treatment of ischemic stroke (Pubmed). 

  • Investigation of size- and dose-dependent endocytosis and toxicity of silica nanoparticles (Pubmed).

  • Targeted delivery of anti-cancer drug mediated by the enzyme degradation of gelatin nanoparticles to treat breast malignancy (Pubmed).